School of Physics and Astrophysics

Postgraduate research profiles

Contact

Taib Nurul Izza

Phone: (+61 8) 6488 1132


Start date

Nov 2012

Submission date

Nov 2016

Taib Nurul Izza

Thesis

Magneto-responsive Nanoparticles for Drug Delivery

Summary

The aim of this project is to develop a mesoporous silica nanoparticle-based nanocarrier that can remotely release bioactive agents in a controlled manner in response to an alternating magnetic field. Mesoporous silica shows very interesting properties for biomedical applications as it exhibits a high tolerability in vivo, is non toxic, simple to functionalize and is bio-compatible. The superparamagnetic iron oxide nanocrystals will be trapped inside the mesoporous silica matrix in order to provide the heating capability under alternating magnetic fields. Macrocyclic molecules will be constructed as temperature-responsive gatekeepers for the bioactive agents trapping them inside the silica matrix. The macrocyclic gatekeepers will be designed to open when there are changes in temperature to release the drugs. The investigation will look to improve our understanding of the mechanism by which these nanocomposites release their drugs. The investigation will then look at how to optimize the properties of the nanocomposite to maximize our ability to provide effective on demand drug delivery.

Why my research is important

Many drugs’ potencies and therapeutic effects are limited because of the partial degradation that occurs before they reach a desired target in the body. Organic based carriers such as polymeric nanoparticles or liposomes suffer from poor stability owing to biochemical attack and swelling. Hence, in these soft materials it is difficult to achieve zero premature release of drugs. It is critical that drug carrier should not degrade or leak until it reaches its destination securing the release of high local concentrations of the drugs at the target. It is very crucial need to develop drug carrier that exhibits homogeneous in ensuring homogeneous drug distribution through the matrix, which can affect the release rate. MCM-41 are chemically homogeneous with well-defined porosity and biocompatible. These mesoporous materials can host and protect against biological degradation bioactive agents stored within inorganic porous matrices. It also has a hexagonal or honeycomb packing of uniform mesopore channels, which means that there is no interconnectivity between individual porous channels. This unique properties renders the “no leaking” capability even in the case of incomplete capping meaning that the individual channel can still serve as independent reservoirs for drug encapsulation and release as long as both ends of a given channel are capped.

Funding

  • Australian Research Grant


 

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Last updated:
Monday, 2 August, 2010 2:54 PM

http://www.physics.uwa.edu.au/1023927