School of Physics and Astrophysics

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Rainer Scharli

Phone: (+61 8) 6488 2738


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Rainer Scharli

Thesis

Establishment of Routine Production of the Cyclotron-Derived PET Isotope 89Zr: Reliable Method for Specific Activity Determination

Summary

The PET metallo-radionuclide 89Zr, with its relatively long half-life (78hr, b+mean=0.397MeV; 23%) is a candidate for immuno-PET imaging and 'dose-scouting' for radioimmunotherapy (67Cu, 177Lu), particularly when extended monoclonal-antibody (mAb) circulation time facilitates tumour penetration. Challenges in purification of 89Zr and its radiolabelling to mAb, plus achievement of adequate specific activity have restricted its use. Introduction of an isothiocyanate group to the desferrioxamine-based conjugation of mAb (Perk, Nature_Protocols, 2008) plus improvements in cyclotron solid-targetry will likely expand applications of 89Zr. This presentation reports

reliable measurement of specific activity of 89Zr. This follows successful solid-targetry production of radionuclidically-pure (>98%, HPGe gamma-spectroscopy) & chemically-pure (

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Last updated:
Monday, 2 August, 2010 2:54 PM

http://www.physics.uwa.edu.au/1023927