School of Physics and Astrophysics

Postgraduate research profiles

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Thomas Greig

Phone: (+61 8) 6488 2738


Supervisors

Start date

Dec 2011

Submission date

Dec 2015

Thomas Greig

Thesis

Relative performance of non-invasive quantification of fat in human livers using magnetic resonance imaging and proton magnetic resonance spectroscopy against invasive quantification using liver biopsy

Summary

Hepatic steatosis is one of the most common liver disorders in the developed world today, with alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) being the two most common conditions being associated with fatty liver. These two conditions encompass a wide spectrum of liver diseases and it has been demonstrated that the presence of free fatty acids in the liver associated with these diseases are linked to higher rates of malignancy, and that hepatic steatosis might in fact contribute to the development of type-2 diabetes through an interference with insulin signalling. Currently liver biopsy is seen as the gold standard for the assessment of liver fat (diagnosis and grading), but this method is expensive, invasive and has a high sampling error associated with it due to the heterogeneous nature of steatosis and the fact that only 1/50000 of the liver is sampled during biopsy. However, with the increasing capabilities of medical imaging modalities, other non-invasive diagnostic techniques have been identified, such as, proton magnetic resonance spectroscopy (MRS) and the three-point Dixon (3PD) method. These techniques have shown significant promise in accurately quantifying fat fractions in the liver however, they have been found to experience significant variability in results due to what fat-water separation methods and sequences are employed.

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Last updated:
Monday, 2 August, 2010 2:54 PM

http://www.physics.uwa.edu.au/1023927