School of Physics and Astrophysics

Postgraduate research profiles

Contact

Juanita Lopez Gaitan

Phone: (+61 8) 9346 4931


Start date

Apr 2012

Submission date

Apr 2019

Juanita Lopez Gaitan

Juanita Lopez Gaitan profile photo

Thesis

Spatio-temporal correlation of normal tissue function and radiation dose: improving radiotherapy to the upper-abdomen

Summary

Radiotherapy has a significant role in the management of cancers of the upper abdomen but high dose radiotherapy has been considerably limited by potential adverse normal tissue responses, in particular that of the kidney.

The principal aim of the project is to obtain a better understating of kidney response when a patient is receiving radiotherapy for an upper-abdominal cancer. This involves monitoring the spatial and temporal changes in kidney function for correlation with delivered three-dimensional radiation dose distribution.

The PhD research integrates an observational clinical trial study called “Radiotherapy of Abdomen with Precise Renal Assessment with SPECT Imaging, (RAPRASI)” that is being conducted at Sir Charles Gairdner Hospital in Perth, Western Australia.

Why my research is important

The relevance and importance of this research was highlighted on the Quantitative Analyses of Normal Tissue Effects in the Clinic (QUANTEC) review of 2010.

Current partial-kidney irradiation risk estimates are still based on dose-volume models of response which fail to take into account important factors like the spatial distribution of both radiation dose and existing kidney function.

A model for kidney spatio-temporal response will be derived that will not only expand knowledge, but also be used to improve radiation therapy treatment planning for upper-abdominal disease.

Funding

  • Australian Government Department of Health and Ageing


 

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Last updated:
Monday, 2 August, 2010 2:54 PM

http://www.physics.uwa.edu.au/1023927