School of Physics and Astrophysics

Postgraduate research profiles

Contact

Blake Segler


Start date

Mar 2014

Submission date

Sep 2017

Blake Segler

Blake  Segler profile photo

Thesis

Modelling Tumour Vasculature and Its Response To Anti-Angiogenic and Radiation Therapies

Summary

We are collaborating with the University of Wisconsin on a model of tumours and their vasculature which is the first in the world to be able to take in individual patient data, such as PET or CT scans, and use these to generate a simulation of the tumour belonging to that specific patient. Drawing on knowledge of biology, computer science, mathematics and physics, we are able to then evolve this system over time in order to see what the tumour might look like two weeks from now, as well as how this would be affected by different courses of anti-angiogenic drugs, which affect the vasculature present. We’re constantly expanding our model so that in the future, we’ll be able to predict the outcome of every possible scenario of chemotherapy, radiotherapy, or other treatment strategies, in order to ensure that we achieve the best possible outcome for every patient, based on their specific circumstances.

Why my research is important

Cancer is one of the leading causes of death in the developed world and constitutes approximately one in seven of all human deaths. Although significant research efforts have been devoted to the understanding and treatment of cancer, our success in these endeavours continues to be limited. This is in part due to the great complexity and variability in the condition itself. The term cancer represents an extremely large family of diseases, with tumours occurring in different locations within the body and with their own individual biology. A successful treatment of these tumours must account for this. Our model takes advantage of various molecular imaging techniques in order to incorporate patient-specific data. In doing this, we are able to account for the biological variability of tumours and ensure that an optimal treatment strategy is chosen based on each individual patient’s conditions. Our research is helping to ensure that in the future, every patient will have the best chance of beating their tumour.

Funding

  • Hackett Postgraduate Scholarship
  • Bruce and Betty Green Postgraduate Research Top-Up Scholarship


 

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Last updated:
Monday, 2 August, 2010 2:54 PM

http://www.physics.uwa.edu.au/1023927